Kohsuke Takeda Selected Research

MAP Kinase Kinase Kinase 5

1/2022	ASK1 signaling regulates phase-specific glial interactions during neuroinflammation.
4/2021	ASK1 suppresses NK cell-mediated intravascular tumor cell clearance in lung metastasis.
12/2017	ASK1 facilitates tumor metastasis through phosphorylation of an ADP receptor P2Y12 in platelets.
7/2011	Apoptosis signal-regulating kinase 1 inhibits hepatocarcinogenesis by controlling the tumor-suppressing function of stress-activated mitogen-activated protein kinase.
1/2011	Apoptosis signal-regulating kinase 1 and cyclin D1 compose a positive feedback loop contributing to tumor growth in gastric cancer.
1/2011	Identification of novel ASK1 inhibitors using virtual screening.

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Kohsuke Takeda Research Topics

Disease

6	Neoplasms (Cancer) 04/2021 - 01/2011
3	Inflammation (Inflammations) 12/2016 - 01/2011
3	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 11/2012 - 02/2006
3	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2011 - 06/2002
3	Parkinson Disease (Parkinson's Disease) 12/2010 - 02/2006
2	Neoplasm Metastasis (Metastasis) 04/2021 - 12/2017
2	Rupture 01/2021 - 01/2019
2	Stomach Neoplasms (Stomach Cancer) 12/2012 - 01/2011
2	Carcinogenesis 01/2011 - 04/2009
1	Autoimmune Diseases (Autoimmune Disease) 06/2022
1	Familial Mediterranean Fever (Periodic Disease) 06/2022
1	Neuroinflammatory Diseases 01/2022
1	Idiopathic Pulmonary Fibrosis 01/2021
1	Mitochondrial Diseases (Mitochondrial Disease) 01/2021
1	Glioma (Gliomas) 03/2017
1	Leukemia 03/2017
1	Obesity 12/2016
1	Pseudohypoaldosteronism 01/2016
1	Hypertension (High Blood Pressure) 01/2016
1	Inborn Genetic Diseases (Disease, Hereditary) 01/2016
1	Virus Diseases (Viral Diseases) 08/2015
1	Lymphedema (Milroy Disease) 06/2015
1	Infections 04/2014
1	Melanoma (Melanoma, Malignant) 04/2014
1	Contact Dermatitis (Eczema, Contact) 04/2014
1	Hypersensitivity (Allergy) 04/2014
1	Type 2 Diabetes Mellitus (MODY) 06/2013
1	Diabetes Mellitus 06/2013
1	Burns 06/2013
1	Contracture 06/2013
1	Hepatocellular Carcinoma (Hepatoma) 07/2011
1	Hypoxia (Hypoxemia) 03/2011
1	Cardiovascular Diseases (Cardiovascular Disease) 01/2011
1	Wounds and Injuries (Trauma) 03/2007
1	Alzheimer Disease (Alzheimer's Disease) 02/2006
1	Septic Shock (Toxic Shock Syndrome) 06/2005
1	Huntington Disease (Huntington's Disease) 06/2002
1	Spinocerebellar Ataxias (Spinocerebellar Ataxia) 06/2002

Drug/Important Bio-Agent (IBA)

6	MAP Kinase Kinase Kinase 5IBA 01/2022 - 01/2011
5	Phosphotransferases (Kinase)IBA 01/2016 - 02/2006
2	Proteins (Proteins, Gene)FDA Link 06/2022 - 04/2014
2	Pharmaceutical PreparationsIBA 06/2022 - 12/2012
2	Monoclonal AntibodiesIBA 06/2022 - 11/2012
2	MAP Kinase Kinase Kinases (MAP Kinase Kinase Kinase)IBA 01/2022 - 01/2011
2	Proteasome Endopeptidase Complex (Proteasome)IBA 01/2021 - 01/2019
2	p38 Mitogen-Activated Protein KinasesIBA 04/2014 - 03/2011
2	CytokinesIBA 04/2014 - 04/2009
2	Insulin (Novolin)FDA Link 06/2013 - 03/2011
2	Mitogen-Activated Protein KinasesIBA 07/2011 - 01/2011
2	polyglutamineIBA 02/2006 - 06/2002
1	Single-Domain AntibodiesIBA 06/2022
1	Interferon-gamma (Interferon, gamma)IBA 04/2021
1	Biological ProductsIBA 01/2021
1	HSP47 Heat-Shock Proteins (Heat Shock Protein 47)IBA 01/2021
1	Molecular Chaperones (Chaperone, Molecular)IBA 01/2021
1	CollagenIBA 01/2021
1	Phosphoprotein Phosphatases (Phosphatases, Protein)IBA 01/2021
1	Purinergic P2 Receptors (ADP Receptor)IBA 12/2017
1	Adenosine Diphosphate (ADP)IBA 12/2017
1	WP1066IBA 03/2017
1	alpha- cyano- (3,4- dihydroxy)- N- benzylcinnamideIBA 03/2017
1	ruxolitinibIBA 03/2017
1	InflammasomesIBA 03/2017
1	Cysteine Proteases (Cysteine Protease)IBA 12/2016
1	Lysine (L-Lysine)FDA Link 01/2016
1	Alanine (L-Alanine)FDA Link 01/2016
1	Proline (L-Proline)FDA Link 01/2016
1	Interferon Type IIBA 08/2015
1	JNK Mitogen-Activated Protein KinasesIBA 04/2014
1	Antiviral Agents (Antivirals)IBA 04/2014
1	Poly I-CIBA 04/2014
1	Double-Stranded RNA (RNA, Double Stranded)IBA 04/2014
1	Tretinoin (Retinoic Acid)FDA LinkGeneric 04/2014
1	RNA Helicases (RNA Helicase)IBA 04/2014
1	Interferon Regulatory Factor-3 (Interferon Regulatory Factor 3)IBA 04/2014
1	HaptensIBA 04/2014
1	Interleukin-17 (Interleukin 17)IBA 04/2014
1	Blood Glucose (Blood Sugar)IBA 06/2013
1	Epidermal Growth Factor (EGF)IBA 12/2012
1	Trastuzumab (Herceptin)FDA Link 12/2012
1	Death Domain ReceptorsIBA 07/2011
1	Mitogen-Activated Protein Kinase Kinases (MEKs)IBA 03/2011
1	Small Interfering RNA (siRNA)IBA 01/2011
1	Cyclin D1IBA 01/2011
1	Reactive Oxygen Species (Oxygen Radicals)IBA 04/2009
1	Superoxide Dismutase-1IBA 06/2008
1	OligonucleotidesIBA 03/2007
1	Guanosine Triphosphate (GTP)IBA 02/2007
1	GTP-Binding Proteins (G-Protein)IBA 02/2007
1	Leucine (L-Leucine)FDA Link 02/2007
1	Protein Kinases (Protein Kinase)IBA 02/2007
1	LipopolysaccharidesIBA 06/2005

Therapy/Procedure

5	Therapeutics 06/2022 - 12/2012
1	Immunotherapy 04/2021
1	Abdominoplasty 06/2013